A Brief Guide To Freeze Drying

Freeze-drying—technically known as lyophilisation, lyophilization, or cryodesiccation—is a dehydration process typically used to preserve a perishable material or make the material more convenient for transport. Freeze-drying works by freezing the material and then reducing the surrounding pressure to allow the frozen water in the material to sublimate directly from the solid phase to the gas phase.

Properties of freeze-dried products:

If a freeze-dried substance is sealed to prevent the reabsorption of moisture, the substance may be stored at room temperature without refrigeration, and be protected against spoilage for many years. Preservation is possible because the greatly reduced water content inhibits the action of microorganisms and enzymes that would normally spoil or degrade the substance.

Freeze-drying also causes less damage to the substance than other dehydration methods using higher temperatures. Freeze-drying does not usually cause shrinkage or toughening of the material being dried. In addition, flavours, smells and nutritional content generally remain unchanged, making the process popular for preserving food. However, water is not the only chemical capable of sublimation, and the loss of other volatile compounds such as acetic acid (vinegar) and alcohols can yield undesirable results.

Freeze-dried products can be rehydrated (reconstituted) much more quickly and easily because the process leaves microscopic pores. The pores are created by the ice crystals that sublimate, leaving gaps or pores in their place. This is especially important when it comes to pharmaceutical uses. Freeze-drying can also be used to increase the shelf life of some pharmaceuticals for many years.

Pharmaceutical and biotechnology:

Pharmaceutical companies often use food freeze dryer to increase the shelf life of the products, such as vaccines and other injectables. By removing the water from the material and sealing the material in a vial, the material can be easily stored, shipped, and later reconstituted to its original form for injection. Another example from the pharmaceutical industry is the use of freeze drying to produce tablets or wafers, the advantage of which is less excipient as well as a rapidly absorbed and easily administered dosage form.

Freeze drying equipment:

There are essentially three categories of freeze-dryers: the manifold freeze-dryer, the rotary freeze-dryer and the tray style freeze-dryer. Two components are common to all types of freeze-dryers: a vacuum pump to reduce the ambient gas pressure in a vessel containing the substance to be dried and a condenser to remove the moisture by condensation on a surface cooled to −40 to −80 °C (−40 to −112 °F). The manifold, rotary and tray type freeze-dryers differ in the method by which the dried substance is interfaced with a condenser. In manifold freeze-dryers a short usually circular tube is used to connect multiple containers with the dried product to a condenser. The rotary and tray freeze-dryers have a single large reservoir for the dried substance.

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Quality Output With Stick Packing Machine & Sachet Packing Machine

The taste of candy stick will be so mesmerizing and attractive that no one else in the world will be missing the taste. Packing the stick in the perfect order and in the perfect sequence is not a simple task as many people are thinking. There will be a number of difficulties present in this process. If the process of stick packing is done with the help of manual labor, it will take more time for the process of packing. It is a hard necessity for the industry to make use of the advanced models of Stick Packing Machine. The best thing about the packing machine is that it will provide best production line for the sequencing of the packages in perfect order and it is also very easy to sort out the production line in certain order for shuffling the flavor. Compared to the old model of Stick Packing Machine, the current version is far more powerful and it will do things in the speed of lightning.

Sachet has become one of the most popular forms of marketing in the recent days. Starting from shampoo to cooking oil, it is now very common to find sachets available in many places. The process of filling sachet takes more time and effort to make sure that the content and the sealing has been done in a perfect manner. To assist people in doing it in a perfect manner, Sachet Packaging Machine is now available. Depending on the size and the demand, there are different types of machines now available with different capacity and also the speed of production line. Depending on the demand of customer, customization can be done in a number of features of the machine.

In order to preserve the food products that are going to be stored for a long period of time, the food processing industry must remove the heat out of the production process immediately and freeze the food to make sure that it is not being decayed or getting contact with the harmful micro organisms that are present in the atmosphere. With the help of simple and powerful Food Freeze Dryer, preserving food is not a matter of concern. It is very much useful for processing solid based food items. Filling chocolates in the respective container is one of the processes that need to be done in a careful manner. If there is any loss in the weight of the chocolate, it will impact hardly in the marketing chain. Advanced models of One-shot chocolate depositing production line can help the industry to improve the processing capacity to a great extent. It is most suitable for mass manufacturing of best quality chocolates. The quality and quality of the chocolate will be preserved as it is.

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A Brief Guide to The Tablet Coating Procedure

A lot of solid pharma dosage mediums are manufactured with coverings, either on the outer surface of the capsules, or on substances distributes within gelatin pills. Tablet coating caters a great deal of purposes:

• Safeguards the capsule form abdomen acids

• Safeguards the abdomen lining from volatile drugs like enteric covered aspirin.

• Offers a delayed discharge of the drug

• Assist sustain the shape of the capsule

Preferably, the capsule must discharge the substance steadily and the medication must be accessible for digestion beyond the abdomen. The covering can be formulated specially to control how quickly the capsule melts and where the accessible medications are to be immersed into the body following eating.

Several aspects can influence the end-use properties of pharma capsules:

• Coating procedure

• Chemical composition

• Storage & environmental monitoring

• Drying period

Coating procedure design and control:

Tablet film coating system happens in a regulated ambiance within a punctured revolving drum. Slanting baffled slotted into the drum & airflow within the drum offer modes of blending the capsule bed. Consequently, the capsules are raised and turned from the sides into the hub of the drum, revealing each capsule surface to a constant volume of deposited coating.

Then the liquid spray covering is dried onto the capsules by heated air driven via the capsule bed from an inlet fan. The flow of air is controlled for heat and volume to offer controlled drying & extracting tempos, and at the same time, sustaining the drum pressure a little negative relation to the room to offer an absolutely isolated ambiance to the operator.

Tablet coating tools may comprise coating pan, cartooning machine, polishing pans. Blenders & mixtures, mills, fans, steam jackets, homogenizers, exhaust & heating pipes, filters and scales. Table coating practice may comprise sugar coating or film coating.

The coating practice is generally a batch impelled job including the below mentioned phases:

• Batch identification & recipe selection

• Loading or dispensing

• Warming

• Spraying

• Drying

• Cooling

• Unloading

A control unit should thus offer adaptability in the way in which precise & recurring regulation of the coating ambiance is accomplished and will comprise the below mentioned features:

• Accurate loop control with set point profile programming

• Chronological control for complicated control strategies

• Recipe management system for simple parameterization

• Safe accumulation of online data from the coating unit for analysis & evidence.

• Local operator display with apparent graphics & controlled access to limitations.

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The Challenges In Pharmaceutical Packaging

When it comes to challenges of pharmaceutical packaging the foremost thing that comes in mind are the issues related to the protective means for controlling contamination. This is exactly where most of the pharmaceutical packaging companies face trouble. Once, the pharmaceutical products roll off the production companies, the concern to protect the products from contamination shifts to the packaging industry.

With the arrival of several life saving drugs, one of the major issues that many pharmaceutical packaging companies are facing is producing primary packaging components, which are compatible with the chemical components forming the products. Many of the elements in the drugs are highly sensitive to certain ingredients. Hence, the products have to be sealed and packed to avoid any leakage.

Pharmaceutical packaging has always been innovative and creative, with new technologies bringing up a variety of packaging models such PET bottles and blister packs, among others. Several cost effective solutions have also been introduced to make pharmaceutical packaging more affordable. Consumers are more conscious about the quality of pharmaceutical products and their visual appearance. Therefore, manufacturers need to take these issues seriously and ensure quality packaging as well.

Pharmaceutical packaging is more than just filling the content into a colorfully designed and labeled container. It demands an extreme degree of safety until the product reaches the end users and brought to use. Therefore, it is very different from other commercial product packaging. The prime focus of the packaging is to protect the drug content from harmful external elements with different protection levels and make it perfectly safe for shipping and distribution.

The stability of the products and the compactness of chemical composition entirely depend on how the drugs are packed. Ideally, there is no exact material that can guarantee to balance drug properties. It is experience, knowledge of materials and judgment of the pharmaceutical packaging company that determines the success of the pharmaceutical products.

There are many drugs which are highly sensitive to sulfur. Being a common component in few rubber elastomeric formulations, it is another challenge for pharmaceutical packaging. Other than sensitivity what matters the most in pharmaceutical packaging is the way the products are going to be used. The packaging of the drugs highly depends on their uses. Take stopper and vial as instances. Packaging companies need to know that how the products will to be used when landed between the end users. If packaging companies are unaware of the kind of needle to be used or confused whether they will be a multi-dose application, it is really difficult to handle the issue once they are in the field. Such issues generate problems because the chemical composition is typically proportionate during their stability.

To buy a whole range of reliable pharma packing machines including sachet packaging machine, blister packing instrument, Food freeze dryer, cartooning machines, etc contact SaintyCo – China’s leading manufacturer of pharmaceutical instruments.

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The Pharma Machinery Industry Is Blossoming Quite Fast

Pharmaceuticals Machines & Equipments are blossoming on efficient leadership, engineering brilliance, cutting-edge technology and professional approach. A broad range of high quality Pharmaceutical Machineries & Equipments from production to packaging are accessible in the market that is empowered with improved technology. The equipments accessible for Pharmaceutical Industry are of all sizes for manufacturing of Tablets, Capsules, Ointments, Cosmetics, Liquid.

With the expansion of pharmaceutical firms, the pharmaceutical equipment manufacturers are also upgrading themselves to fulfill the challenges arising out of the requirements set by the pharmaceutical industries. Most of the leaders in the field are looking towards advanced market for their pharmaceutical Machinery. With the growing significance of machineries which integrate advanced technologies, the levels are also increasing. China is increasingly becoming an active hub for the pharma industry world over. Pharmaceutical scientists across the board need instrumentation companies to develop smaller, faster, and more-accurate tools. Currently to meet new international requirements in terms standards and technology, the Pharma Machinery manufacturers are upgrading their machineries.

Here in this article, we will talk about different pharma machineries that are used quite extensively in the industry.

Cartoon sealing or cartoning machines:

Cartoning machines are suitable for carton packing, and also can be used for single use or production line. It adopts adhesive tape to seal carton, economy and fast, easy adjust. It can finish the sealing both top and bottom. Also you can adjust the height and width for different cartons. Cartoon Sealing Machines are mainly used in Pharmaceutical, Chemical and Cosmetic Industries.

Pharmaceutical Conveyor:

In pharmaceutical packaging, conveyors not only role as a “highway” system to coordinate product flow between machines, they can also maximize packaging line efficiency. Selecting and integrating the conveying system for pharmaceutical packaging environments requires careful and early consideration. Failure to give proper attention to the conveyor system can result in waste, excess costs, and higher cycle times. Conveyor mechanisms are used as components in automated distribution and warehousing. It is considered a labor saving system that allows large volumes to move rapidly through a process, allowing companies to ship or receive higher volumes with smaller storage space and with less labor expense.

Blister Packaging Machine:

In pharmaceutical industry Blister Packing Machines are used for the packing tablets, capsules, pills and other similar products packing.

Tube filling and sealing machines:

Automatic Tube Filling and Sealing Machines fill ointment/cream in cylindrical aluminium collapsible/ lami/ coextruded plastic tubes and close it absolutely safely and symmetrically.

Capsule filling machines:

High Speed Automatic Capsule Filling machines are suitable for filling powders and pellets. These are versatile machines with several outstanding features both functional and mechanical.

What an Ideal Pharmaceutical Packaging Requires

Pharmaceutical packaging is more than just filling the content into a colorfully designed and labeled container. It demands a superior level of safety until the product reaches the end users and brought to use. Hence, it is very different from other commercial product packaging. The prime focus of the packaging is to shield the drug content from damaging external elements with diverse protection levels and make it entirely safe for shipping & distribution. There are different pharma packing machines available these days, for example Sachet Packaging Machine, stick packing machine, etc that make things easier. Let’s find out what a perfect pharmaceutical packaging requires:

Protection from exterior elements- Since pharmaceuticals involve chemicals in their manufacturing, they need protection from external elements like oxygen, water vapor, dust, etc. so as to avoid chemical reaction and deformation of their actual composition. Using appropriate element and sealing technique, a barrier is create against expected external factors.

Physical Protection- Pharmaceuticals can be in the form of solid (Tablets/Capsules), powder, cream or liquid. Hence, the content has to be packed accordingly, though almost every medicine needs protection from vibration, shock, compression, temperature, etc. enclosed in the package. For more delicate items additional layer of sheets are used, like cardboard, bubble sheets and paper strings are used.

Information transmission - Packaging of the product has to contain information related to their uses, transportation, recycling/ dispose, etc. on the label in order to maintain safety of the product. The information might be printed in the form of text, note, warning or symbol.

Comfort - Comfortable features have to be included for easy handling, distribution, display, opening, sale, re-closing, use and re-use. This provides the package extra efficiency and safety to the pack, no matter how they are handled.

Agglomeration or Containment - Medicinal items need to be grouped together in one package for efficient transportation and handling. Mostly, tablets and capsules (in small numbers, preferably 5/10/12) are packed between metallic/ plastic sheets joined and sealed together. Many of them are also bottled. The choice of containment depends on the type of medicine to be packed.

Marketing - Apart from safety and efficiency, pharma packaging must also have the marketing ability. Packaging is not just to provide production to the product but also to encourage potential buyers to purchase the product. For the purpose, packages are labeled with fine and attractive print.

For a variety of pharma related machineries such as Tablet film coating systems , cartoning machine, sachet packaging machine and others please visit us at SaintyCo and save big.

World Class Medical Packing Machines For Improved Processing Speed

There are different types of mechanisms now being followed in the medical industry for processing capsules and tablets. In most of the cases, the medicines will come in the form of whole compound and they can be consumed directly. Some of the medical bases need to be processed in such a manner that they are contained carefully inside a thin film of sugary substance to make sure that they are not affecting people when they are taking the capsules. The thickness of the film must be mild and it should not affect the quality of the tablet at any point of time. For this purpose, advanced models of Tablet Film Coating System is now available. They will add a very mild coating of the sugary substance in its base and it will also add color to the tablet in the selective quantities.

Blending is one of the most important processes in the production of medical compounds. For a medicine that need to fight with various problems in the body, many medical compounds need to be added to the base and the base need to be blended in a perfect manner to make sure that the contents of the capsule is being mixed up in a perfect manner. For this purpose, Bin blender is much helpful. The blender comes with an invertible furnace and it can be violently agitated in the laterals for mixing up the compounds in a perfect manner. The contents can be added and removed from the blender in a very simple manner.

At the time when the capsules are being finished in their process of production and manufacturing, they will be waiting for the process of packing for finishing up the entire process. This process is not a simple one alike other industries that are packing products. The tablets and capsules must be present in a special container and the count of the tablets that are flowing through the packing line must be uniform. For this purpose, best performing Spheronizier is now available in the market. The advantage of this apparatus is that they will keep the tablets in special hopper that will send out only the required number of capsules. The container of Spheronizier will be always rotated and in the output it will form a rope like chain of the tablets and capsules. The combined package of Pellet Extruder and Spheroniziers will process of the tablets in a particular order and ensure that there is nothing else left out in the production line without being processed. As the process is being combined, it will ensure that the tablets are arriving in separate batches right at the time when they are coming out of the processing field.

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